Feasibility and Biological Activity of a Ketogenic/Intermittent-Fasting Diet in Patients With Glioma

Schreck, Karisa C.; Hsu, Fang-Chi; Berrington, Adam; Henry-Barron, Bobbie; Vizthum, Diane; Blair, Lindsay; Kossoff, Eric H.; Easter, Linda; Whitlow, Christopher T.; Barker, Peter B.; Cervenka, Mackenzie C.; Blakeley, Jaishri O.; Strowd, Roy E.

Abstract

OBJECTIVE: To examine the feasibility, safety, systemic biological activity, and cerebral activity of a ketogenic dietary intervention in patients with glioma.

METHODS: 25 patients with biopsy-confirmed WHO Grade 2-4 astrocytoma with stable disease following adjuvant chemotherapy were enrolled in an 8-week GLioma Atkins-based Diet (GLAD). GLAD consisted of 2 fasting days (calories

Citation

Schreck, K. C., Hsu, F.-C., Berrington, A., Henry-Barron, B., Vizthum, D., Blair, L., Kossoff, E. H., Easter, L., Whitlow, C. T., Barker, P. B., Cervenka, M. C., Blakeley, J. O., & Strowd, R. E. (2021). Feasibility and Biological Activity of a Ketogenic/Intermittent-Fasting Diet in Patients With Glioma. Neurology, 97(9), e953-e963. https://doi.org/10.1212/wnl.0000000000012386

• Journal Article Type: Article
• Acceptance Date: May 28, 2021
• Online Publication Date: Jul 7, 2021
• Publication Date: Aug 31, 2021
• Deposit Date: Jul 14, 2021
• Publicly Available Date: Jul 8, 2022
• Journal: Neurology
• Print ISSN: 0028-3878
• Electronic ISSN: 1526-632X
• Publisher: American Academy of Neurology
• Peer Reviewed: Peer Reviewed
• Volume: 97
• Issue: 9
• Pages: e953-e963
• DOI: https://doi.org/10.1212/wnl.0000000000012386
• Keywords: Clinical Neurology
• Public URL: https://nottingham-repository.worktribe.com/output/5784763
• Publisher URL: https://n.neurology.org/content/early/2021/07/07/WNL.0000000000012386